Exact(8)
We demonstrate that neither template backbone nor the architecture of the active site is perturbed by the oxoG anti)C and oxoGA pairs.
In this approach, proteins can be designed by transcendentally setting AA sequences compatible with existing or postulated template backbone structures (de novo design) or by making calculated variations to a known protein structure and its sequence (protein redesign) [169].
For sphingolipids (SP), the two chains corresponding to a long chain base and an N-acyl chain are also drawn with the chain termini on the left of the ceramide template backbone and the head groups are on the right.
For two out of the eight lipid categories, GL and GP, the radyl hydrocarbon chains - sn1, sn3 and sn3 chains at positions 1, 2 and 3 on the glycerol backbone corresponding to stereo chemical numbering (sn) scheme - are drawn with the chain termini on the left using attachment points on the template backbone and the appropriate head groups are shown on the right (Figure 2).
The template backbone, the ligand, and the water molecules were fixed, and ten receptor models were constructed based on the template backbone.
In both instances, the template backbone is stretched to fit the DNA into the catalytic core of the polymerase.
Similar(50)
Rather, the rotation of 8-oxoG to syn is likely a consequence of the steric clash between O8 of 8-oxoG and the template phosphate backbone.
Arg336 was bent toward the template DNA backbone and formed a hydrogen bond with the phosphate oxygen.
Intensive research on ways to make RadLex and the RSNA SR templates the backbone of structured is ongoing [17, 18].
In addition, more rational approaches have focused on the incorporation of phosphotyrosine mimetics into specific peptide templates (peptidomimetic backbones).
v) Root mean square deviation (RMSD) between GTS1 model and the crystal templates Cα backbones of the closed templates were 2.408 Å for 2gnq and 3.192 Å for 2h9l.
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