The variation in selected doses reflects the history of investigation of this therapy outside the hemophilia setting, in which there was often uncertainty regarding the dose required for optimal hemostatic efficacy, tempered by early concerns that this treatment could have thrombogenic potential.
However, advances in the use of autologous fat were tempered by the limited efficacy of fat injection, since transplants lost 50% of their volume after only one year (Klein and Elson 2000).
Enthusiastic acceptance of the 'supranormal' O2 delivery concept, produced by the infusion of fluid volume, inotropic agents and blood products [ 5], has been tempered by studies finding no efficacy [ 6], or even increased mortality [ 7], with this approach.
However, enthusiasm regarding the successes with in vitro and xenograft models has been tempered by the lack of efficacy as single-agent therapy in CRC as well as significant mucosal toxicity (Staal and Langerak, 2008; Strosberg et al, 2012).
First, as stated above, diuretics lack of efficacy has to be tempered down with regard to the high risk of bias in available studies.
All statements on the efficacy of treatments must be tempered by the potential biases and uncertainties that result from the choice of patients and therapies.
Any praise for the efficacy of safety nets must be tempered by the realisation that, for one reason or another, these folks could not make it on their own.Read on: Taxing hard-up Americans at 95%(Photo credit: AFP).
These side effects in addition to lack of efficacy to increase lean body mass has tempered the routine use of MA for treatment of cancer anorexia [ 24].
Enthusiasm regarding the efficacy of oxaliplatin/5-FU/LV regimens has been tempered by the associated neurotoxicity which can significantly impair the quality of life of patients and limits the optimal use of oxaliplatin.
This should help decision-makers and clinicians to enhance positive aspects while tempering negative ones, optimising efficacy, quality and, ultimately, access to services.
Finally, there are some conditions in which dapsone was reported anecdotically as being useful, but initial enthusiasm has been tempered with subsequent controversial or contradictory results and/or a total lack of properly controlled trials showing efficacy.
