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Optimism is appropriate but must be tempered against experience and the realities of drug development.
The magnitude of any improvements in sensitivity obtained via this mechanism may need to be tempered against the detrimental effects of destructive interference, occurring when the form of sensory input differs from internal predictions.
In addition, preoperative neoadjuvant radiotherapy and chemoradiotherapy regimens also promise to improve survival (Marsh et al, 1994; Anonymous, 1997; Pahlman et al, 1998; Dahlberg et al, 1999), but their success needs to be tempered against the inevitable morbidity associated with such treatments (Dahlberg et al, 1998).
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But in the ensuing months, both leaders tempered their stance against Islamabad after Pakistan joined Afghanistan, China and the United States in a four-nation effort to start peace talks with the Taliban.
Government officials have also tempered their fiery statements against the white minority and black supporters of the Movement for Democratic Change.
Debenedetti's unmistakable delight in this new scandal, and his sense of solidarity with its perpetrator, is tempered by moral outrage — against his dupes.
To this day, both Martha and Rufus bear enduring grudges – now tempered slightly by time – against a father who wrote songs about his children instead of raising them; and understandably so, given the revelations in Loudon's brutally honest "Hitting You", about a moment of rage regretted for a lifetime.
Being made president-elect hasn't tempered Donald Trump's rage against the media.
IRENE, South Africa — The United States' satisfaction with a 1-1 dragainstnst England was tempered Sunday by the uncertainty of goalkeeper Tim Howard's availability for Friday's World Cup match against Slovenia because of a rib injury.
Set against largely electronic arrangements tempered by acoustic guitars, the voices seem intimate and sure of themselves.
Many of its windows would be tempered, laminated and multilayered for extra protection against explosions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com