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Nevertheless, these procedures involve tedious synthesis steps and normally have economic drawbacks.
The majority of work in this field involves a tedious synthesis of selective macrocyclic ligands for a target metal [5].
Even though several nanoplatforms have been explored for the co-delivery of drugs and genetic materials the translation of these systems to clinical phase is still a challenge, mainly due to tedious synthesis procedures, lack of serum stability, inefficient scalability etc.
The non-covalent approach is more frequently used due to the following properties: (a) the tedious synthesis of pre-polymerization complex is avoided, (b) removal of the imprint molecule is usually accomplished by a continuous extraction, (c) the multiplicity of functionalities is reached into the molecularly imprinted polymer (MIP) binding sites [ 18, 19].
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However, further applications of both strategies are hindered mainly by the tedious multistep synthesis and the associated difficulties in analytical quality control of each synthetic step.
However, many metabolites are not commercially available and many of them may require tedious and expensive chemical synthesis, which often hampers their definitive metabolite identification.
Hence, the synthesis would be tedious and requires careful removal of the structure directing agents to avoid contaminants.
The proposed colorimetric biosensor is advantageous over other conventional methods in terms of convenient operation without any complicated chemical synthesis, modification, or tedious experimental procedures and its simple signal generation and detection by the naked eye.
Exploring an optimal design point during architectural synthesis is a tedious task owing to the orthogonal issues of reducing exploration time and enhancing design quality as well as resolving the conflicting parameters of power and performance.
As R-HAs are not readily available on the market and their classical synthesis is rather tedious, only few synthetic routes using such reactants as starting material have been reported.
The complex synthesis through multistep reactions and tedious purifications based on different monomers or macromolecules limits the practical applications of functional polymers.
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