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For as long as governments manage their public servants centrally, for better or worse, tedious restrictions like these will persist.
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The limited number of naturally occurring rare-cutting restriction enzymes and the slow and tedious engineering of existing restriction enzymes for novel specificities have prompted the design of new strategies for the development of restriction enzymes with specificities for long DNA sequences.
Note that a direct implementation of such a three-stage restriction in the mathematical formulation would be quite a tedious task and make the problem mathematically intractable.
Without a complete genome, identification of the specific methylase for DNA modification to resist restriction enzymes in the host cells is typically a tedious and cumbersome trial-and-error exercise.
Manipulation of the large genomic DNA is tedious and problematic due to size capacity of cloning vectors and multiple restriction endonucleases which make it difficult to find appropriate enzymes for subcloning.
However, working with genomic DNA clones has traditionally been tedious due to their large size relative to cDNA clones and the presence, absence or position of particular restriction enzyme sites that may complicate conventional in vitro cloning procedures.
Tedious, dull.
"So it's tedious, really tedious.
Supposedly tedious, that is.
Tedious, maybe, but "relaxed".
The search became tedious.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com