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This study revealed a potential therapeutic use in ALF of in vivo siRNA technology targeted to oxidative stress regulators.
In conclusion, our results have revealed a potential therapeutic use of in vivo siRNA technology targeted to Keap1 to combat oxidative stress by modulating Nrf2-mediated antioxidant responses and IGFIR survival signaling during the progression of ALF.
In conclusion, our results have revealed a potential therapeutic use of in vivo siRNA technology targeted to Keap1 to decrease oxidative stress by the enhancement of the Nrf2-mediated antioxidant response and the maintenance of the IGFIR survival signaling during the progression of ALF induced by ConA.
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