We employed Illumina GoldenGate DNA methylation technology, which interrogates 1,505 CpG sites in 807 different genes, to further study this association.
Design of an array based technology which interrogates a large number of CpGs across the human genome is a difficult task.
To explore the mechanism(s) by which androgen-dependent PCa cells become resistant to hormonal therapy, we used microarray technology to interrogate the differences in gene expression between androgen-responsive and therapy-resistant cell lines.
Under rare-variant with medium- to high-penetrance models (odds-ratios between 1.6 and 4.0), studies comparable in size to many existing studies are adequate provided the genotyping technology can interrogate more and rarer variants.
To better understand the roles of these EBV-encoded miRNAs in the pathogenesis of NPC, we used the deep sequencing technology to interrogate the EBV miRNA transcriptome in clinical NPC tissues.
The use of MarginProbe or other technology to interrogate the lumpectomy cavity might provide additional data regarding the adequacy of resection.
Here we describe our identification of a C2H2 transcription factor, termed RsrA, using Illumina technology to interrogate a mutant arising from a 4-nitroquinoline-1-oxide (4-NQO) screen of a ΔlaeA mutant.
Following the completion of the P. falciparum genome sequence and the development of microarray technology for interrogating the transcriptome, several studies were published of parasite transcriptomic response to perturbation, including anti-malarial drugs.
We performed reduced representation bisulfite sequencing (RRBS), a technology for interrogating hundreds of thousands of methylation sites with digital precision, on the rat PNS and found characteristic and highly significant patterns relating gene methylation and activity (p≈1.0x10−74) that differed markedly between LCP and HCP genes.
In the past few years, the wave of genome-wide association studies (GWASs) provided a more robust tool to find novel susceptibility loci or genes for cancer susceptibility by using high-throughput genotyping technology to interrogate a large number of tagging polymorphisms in a high density across the whole genome [ 6].
