Exact(5)
The advances in high throughput screening technology for discovery of target molecules and the accumulation of functional genomics and proteomics data at an ever-accelerating rate will enable us to design and discover novel biomolecules and proteins on a rational basis in diverse areas of pharmaceutical, agricultural, industrial, and environmental applications.
As soon as the first ancient DNA was published [11], the key question emerged whether it is possible to use this technology for discovery of genetic differences among hominins, or at least between modern humans and the last extinct hominin group, the Neanderthals.
RNA-seq is also an important genomic technology for discovery of a large number of DNA markers, including SNP and SSR at transcriptome level.
However, the technology for discovery of new cancer biomarkers has recently been questioned for its flaws, such as its qualitative nature, high identification error rate, poor reproducibility and nonspecific absorption matrices [ 25– 27].
Although microarray technology and its applications have evolved considerably over the years to meet a growing range of genomic challenges [ 1], the classical format for microarrays in interrogating the transcriptome (that is, expression microarrays) has been a key technology for discovery in functional and medical genomics.
Similar(55)
The past decade brought even more understanding of the complexity of breast cancer biology through the development and clinical applications of array-based technologies for discovery and prognostication.
We discuss general principles of combinatorial materials screening, followed by the discussion of the opportunities facilitated by combinatorial technologies for discovery and optimization of new sensing materials.
Below, a technical description of the available proteomic technologies for discovery, verification and validation stages is presented, together with certain recent applications particularly in the field of clinical proteomics in the quest of bladder cancer biomarker research.
They are using the company's technology for drug discovery, oil and gas exploration, and financial-market research.
Moreover it constitutes an attractive technology for drug discovery programs, for high content, high throughput screening assays, to assess the potency of new hits and optimize lead compounds, whilst also serving to characterize drugs developed through rational design.
To this end, we report herein the application of an improved technology for target discovery, Random Homozygous Gene Perturbation (RHGP), to identify host-oriented targets that are well-tolerated in normal cells but that prevent influenza-mediated killing of host cells.
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