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This could be due to multiple factors, e.g. low levels of protein expression, technological sensitivities, sample processing, probe set definition or anatomical origin of tissue and actual biological differences between transcript and protein abundance.
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This may be a question of technological sensitivity and so the application of high-resolution massively parallel sequencing technologies is certainly warranted to clarify such findings.
With the use of this model, technological sensitivity was analyzed to identify key research issues that must be pursued in the future.
Despite this success, these experimental methods are limited in protein identification capabilities by several parameters, for instance, by technological sensitivity and organelle purity, and to major plant tissues and organs.
However, with experience and technological advances, reported sensitivities are greater than 80% for both modalities.
Biosensor technology is one area where recent advances in nanomaterials are pushing the technological limits of electrochemical sensitivities, thus allowing for the development of new sensor chemistries and devices.
Smart-seq2 contains technological improvements to increase sensitivity, accuracy, and the number of full-length transcripts.
In this section, we describe the estimates of current ASHP performance, and three scenarios used in the analysis of sensitivity to technological development (Sect. 3.1).
Technological improvements provide the sensitivity required to match the high demands on spatial and temporal resolution and to analyze fast and small signal components of the fMRI response.
Furthermore, it supports the reduction of present power consumption in SFQ circuits by using smaller switching energy as well as the development of more complex circuits because of a reduced sensitivity against technological parameter spread.
Roosegaarde calls this intersection of human sensitivity and technological development "techno poetry".
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