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This review summarizes the current literature on botulinum toxin A in the treatment of Raynaud's phenomenon and examines the proposed mechanisms of action, suggested techniques of administration, and clinical efficacy.
Some instruments such as the Neonatal Behavioral Assessment Scale (NBAS) (Brazelton 1984; Brazelton and Nugent 1995) and the Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scale (Lester et al. 2004) require intensive training of examiners to master the techniques of administration and become reliable in scoring newborn responses.
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This technique of administration of aerosolized medication is commonly used worldwide for the administration of bronchodilators in nebulized form.
The technique of administration of NO into the upstream of the ventilator was first developed in Scandinavia [ 1, 2].
This suggests that the technique of administration may need to be standardised to ensure effectiveness of local anaesthesia.
Provided that a proper technique of administration is used, bronchodilator therapy with MDI is clearly effective [ 2**, 3**].
The technique of administration of bronchodilators in mechanically ventilated patients using an MDI and a spacer is an important factor thaty determines the efficacy of this therapy.
Provided that the technique of administration is appropriate, MDIs are as effective as nebulizers, despite a significantly lower dose of bronchodilator given by the MDI.
The medication container, total volume to be infused and technique of administration will be the same for active and control treatments.
The study protocol had several challenges like the difficulty in maintaining high enough concentrations of aqueous solution of L-N-acetylcysteine in the middle ear due to the technique of administration.
The trough levels stabilized after the first 2 weeks of the study, which according to the authors, could be explained by improved absorption of the drug, better technique of administration, dietary changes or variation in RTV oral clearance.
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