Several high-volume centers have reported standardized techniques with refinements and subsequent outcomes.
It also represents an important step towards improving animal welfare and the three Rs' principles of humane experimental technique: replacement, refinement and reduction.
The applicability and effectiveness of optimization techniques and refinements is highly dependent on the logic under consideration and on the class of problem being solved.
Thus, while nigral transplants clearly work well in select PD cases, the technique needs refinement before it can successfully be performed in a large series of patients.
The lattice parameters were calculated using the unit cell refinement technique and the refined lattice constant values were compared with the standard JCPDF data source files.
However, the techniques require refinement to allow rapid and online measurement of cytokines before the full benefit of such information can be effectively translated into better management of trauma patients.
To facilitate users and obtain the effective local refinement, this paper proposes a local refinement technique.
The XRD pattern was analyzed by refining the experimental data using a standard Rietveld refinement technique.
The main contribution of the work is the concrete abstraction refinement technique based on the modular structure of the model, the dependency graph of the model, and a refinement sampling heuristic similar to delta debugging.
They are very similar to those obtained with the post-refinement procedure described in §4.2, and much more precise than those obtained with the conventional refinement technique.
