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Even after the subgroup analyses based on the digital imaging technique, heterogeneity was only partially ameliorated.
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Secondly, having used the tissue microarray technique, it is possible that tumour heterogeneity was not completely taken into account.
An orthogonal analytical technique for the evaluation of charge heterogeneity was CEX-UPLC, which revealed that the averaged abundances of the main, acidic, and basic isoforms were within the same order of magnitude for both products, being the mean values of 57.0%, 33.2%, and 9.8% (n = 3) for Trastuzumab-Probiomed and 62.5%, 27.3%, and 10.3% (n = 3) for the reference product, respectively.
Since obvious heterogeneity was observed, the meta-regression technique was used to explore the heterogeneity other than threshold effect.
If substantial heterogeneity was found, the meta-regression techniques would be used to explore the reasons for the heterogeneity.
Heterogeneity was further investigated using meta-regression techniques.
The chemical heterogeneity was investigated by SEC-FTIR and fractionation techniques.
Additionally, a great heterogeneity was seen in type of malunions treated and the technique used for the corrective procedure.
A large heterogeneity was found regarding study design, sample size, surgical techniques and methods for preparing platelet concentrates.
However, residual heterogeneity was large.
However, significant heterogeneity was present.
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