Because examining the translational status of maternally supplied sup-26 mRNA (without detecting the zygotic contribution of the same transcript) is technically difficult, we examined total embryonic sup-26 mRNA for evidence of mir-35 -41–dependent regulation.
Lastly, the processes examined are technically complex to measure and, in many ways, the instruments being used are relatively recent developments.
It would be interesting (if technically challenging) to examine primitive cells, to determine whether ChiLS is associated exclusively with poised enhancers prior to cell specification or signal responses.
However, it is technically hard to examine the coexpression of OMP2 with receptor genes, because the copy number of them are very large.
Although it has only been technically feasible to examine peripheral blood DCs from patients with diabetes, when we compared peripheral blood DCs from RA patients we did not find a similar exhausted response to LPS in RA [ 39].
Until it became technically possible to examine hormone action in isolated cells in culture, it was believed that ACTH effects on immune system function could only be indirectly exerted by stimulation of endogenous glucocorticoid production by the adrenals.
The difficulty of risk assessment still exists despite the fact that the studies examined are definitely more technically valid than those of earlier years.
Therefore, we wished to determine whether the effects of Reaper on mitochondrial dynamics could be examined in a more technically amenable system.
However, these studies examined transcriptomes of whole anthers, which, while technically much less challenging than isolating meiocytes (cells undergoing meiosis), does not distinguish between meiocyte gene expression and gene expression in the various other tissues of the anther.
Echocardiographic examinations by operators using mTEE after six-hour bedside training were technically feasible and of sufficient quality in a majority of examined ICU patients.
