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Dominic Coles, the BBC's director of operations, said that the corporation has a high technical pedigree with projects such as the BBC iPlayer but had "got this one wrong".
It helped that their music had both emotional heft and technical pedigree.
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Overall, our work reveals the advantages of technical replicate pedigree-based WES in multiple generations, specifically in relation to interpretation of WES derived genotypes [ 7, 24, 25].
"It's a cocktail of things: rarity, technical sophistication, racing pedigree and continuing competitive success.
They are not dancers of high stylistic pedigree or technical flair, yet they perform with rare freshness and nuance: not as if remembering what they had been taught but as if carrying the idea of the ballet in their heads and delivering it spontaneously.
As a clinical geneticist was formally responsible in each location for patient care, whether it was delivered by a doctor or a nurse counsellor, we were not concerned with assessing performance of the nurse counsellors in relation to technical procedures such as pedigree construction or calculation of risk estimates.
To further control SNP quality, a parent/F1 triplet and four DNA duplicates were used to analyse the pedigree consistency and technical reproducibility, respectively.
By strictly filtering, the genotypes of the finally selected SNPs of all DH lines were completely homozygous, and the DNA pedigree consistency and technical reproducibility were nearly perfect, suggesting the high quality of these selected SNPs.
While evolving versions of exome-enrichment kits continue to address these biases, effects of technical replicate experimental design in pedigree-based WES are poorly understood.
Haeckel filled the first Darwinist system, his Generelle Morphologie (General morphology), with cosmic ambition, new technical terms, ferocious polemic, bold pedigrees all the way up to human beings and taxonomic revisions which promoted amphioxus to a new subphylum, the Acrania or skull-less ones.
First, we used CLAMMS, XHMM, CoNIFER, CANOES and ExomeDepth to call CNVs for an eight-member pedigree, sequenced in three technical replicates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com