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The technical constrain for selecting high MIC mutants in vitro is due to the drug concentration used in the screening of active multiplying cells.
The higher MICs could be explained by the technical constrain imposed by the mutant selection method [ 22] in which the active multiplying cells need to be grown in presence of triclosan concentrations sufficient to isolate resistant mutants from wt strains.
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Patients did not have a short-term or long-term adaptation to Smt mapping due to technical constrains.
A reference case is defined and evaluated taking into account the state of the art of the technology and the related technical constrains.
In contrast, innovations are needed to overcome the technical constrains in drug propellant incompatibility and delivering high-dose drugs with pressurised metered dose inhalers (pMDIs).
The paper has the main objective of presenting the fuel cycle flexibility of the MOSART system while accounting technical constrains and experimental data received in this study.
For this test, the "Checker" program was set for 22-channel output, testing 43 channels with CIs was eliminated due to technical constrains and time limitations of the project.
One of the technical constrains when performing functional studies with HZ is the lack of a unified protocol that yields biomimetic Plasmodium-like HZ crystals of uniform homogeneity and morphology.
The Biotronik Home Monitoring systems transmit an 'IEGM Online' that is shorter than the full-length programmer IEGM due to technical constrains.
In healthcare, not all of the DMUs are producing at the same scale, which might be due to many factors, such as financial constraints, technical constrains, or poor organization.
Moreover, although the CpG positions assayed with the two methods are not exactly the same due to technical constrains (Additional file 1 and Additional file 3: Figure S4), still the analysis of methylation data collected with each one of the two different techniques highlighted a cluster of CpGs with correlated methylation levels within exon 1 of ZBTB12, hypomethylated in MI cases vs controls.
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