But seen as a technical artifact it has physical ones.
The notion of a technical artifact will help to conceptualize and organize some of the central questions and issues in the philosophy of computer science.
For RNA-seq, reverse transcription of mRNA to cDNA followed by cDNA amplification via PCR introduces technical artifact and amplification bias, particularly for lower-abundance transcripts.
However, these conclusions were contradicted by phylogenetic analyses, which showed large genetic distances between cells, and therefore it is unclear if these differences reflect real genomic diversity or technical artifact.
Current approaches in sociotechnical systems consider trust to be either cognitive referring to actors' mental models of each other or technical referring to an actor's trust of a technical artifact.
Evaluating genomic heterogeneity at the single-cell level requires overcoming a number of challenges including isolation of individual cells, effective amplification of a single-cell genome to allow for targeted, exome- or genome-wide sequencing, and bioinformatics approaches to discriminate technical artifact from biological differences [4].
Tests of the effects of varying the size of MS lesions revealed a moderate and consistent dependence of GM volumes on T2 lesion volume, which suggests that GM volumes should be corrected for T2 lesion volumes using a simple scale factor in order to eliminate this technical artifact.
To eliminate this technical artifact, we identified oligonucleotides prone to self-hybridization using an Mfold-based algorithm.
There are several factors to consider with low level mosaicism: are the results due to genuine mosaicism, technical artifact [17], or age related?
Next we selected 10 chips with the least evidence of technical artifact compared with the median across all chips, and constructed expression profiles for each of the five samples by averaging each pair of replicate chips among these 10.
Thus, expression of Tax in malignant OB could be the result of a technical artifact such as promoter leakiness or could be revealing previously unrealized granzyme B promoter activity during OB differentiation.
