Owing to various factors including subtle phenotypic abnormalities, technical limitations, and inherent tissue-specificity, mosaicism is often undetected and underdiagnosed.
Additionally, the MRI data were checked by an experienced radiological technical assistant and no abnormalities were detected.
A further eight cancers were detected because review of the initial films at the time of the technical repeat showed subtle abnormalities that had not previously been appreciated.
Although blood loss during LT is multifactorial, the major causes of excessive IBL are technical difficulties and pre-existing abnormalities of the hemostatic system [ 24].
Does an abnormality of hiPSC-CM from one person reflect true biological abnormality or a technical artefact that has either been introduced during the numerous rounds of making hiPSC and CM or even earlier.
A particularly notable characteristic of HM, besides its scheduled transmissions, is the warning messages that are issued in case of technical dysfunction or detectable clinical abnormality and that are addressed to the physician in charge of the patient via e-mail, fac simile, or text message or via all these means of communication.
Our measurements of stereocilia stiffness did not reveal any abnormality, but owing to technical limitations, these were only performed on immature hair cells, which do not show yet any obvious structural anomaly.
An overview of study characteristics detailing prevalence of cough and chest radiograph abnormalities is provided in the Technical Appendix Table 1.
However, it should be underlined that the mere absence of a given genetic abnormality may simply reflect a technical failure.
Firstly, since samples from 22% of IVF patients could not be screened (due to practical, technical and/or logistical reasons) the incidence of significant abnormalities might be underestimated.
