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Such extreme observations can be due to the presence of very short segments of DNA with deviant copy numbers, to technical aberrations, or a combination.
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For the moment, however, perhaps none stimulated quite as much chatter as the freakish technical aberration that caused chaos in the betting community on Wednesday.
We can surpass our current technical limitations by correcting the aberrations of the 4 π-PM.
Technical comments: 1) The accuracy of correction of chromatic aberration was not estimated, but it is expected to be in the range of measurable values.
This technical limitation does not invalidate our finding that Y-iPSCs aberrations are mainly DNA demethylation failure.
This technical approach is also evidently able to reveal copy number aberrations, as we encountered a 47, XXY neonate in our sample cohort.
Multiplex ligation-dependent probe amplification is a PCR-based technique that detects a large variety of segmental aberrations and gene amplifications in a robust manner (for technical details, see (Schouten et al, 2002).
Since our cohort of ALL patients included samples diagnosed as early as 1996, the fact that the canonical aberrations were not detected at diagnosis could be due to technical limitations of the methods applied at that time.
Somewhat surprisingly, they failed to qualify for the women's team sprint and it was this aberration that indirectly led to the resignation of the technical director, Shane Sutton, paving the way for Harrison to take over.
Integrated approaches that not only account for DNA and RNA aberrations but also document protein function and biochemistry are clearly the next technical horizon [ 60].
Although the identification of these genetic aberrations in plasma cell free-DNA (cfDNA) showed great promise, there are several technical difficulties that challenge their practical and clinical application (Jung et al, 2010).
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