Sentence examples for tdo in from inspiring English sources

Cortisol produced by the adrenal glands activates tryptophan 2,3-dioxygenase (TDO) in the liver, thus increasing kynurenine synthesis [ 47- 49].

A detailed account of evidence against the Trp starvation concept led Moffett and Namboodiri [ 76] to propose a Trp utilization concept as a comprehensive theory of immune-related IDO induction, with particular emphasis on the role of QA in NAD+ synthesis and the tissue distribution of IDO and TDO in health and infectious disease.

Thus, the observed association between kynurenine metabolism (KYN/TRP) and neopterin concentrations throughout the study in both groups suggests an involvement of enzyme indoleamine 2,3-dioxygenase (IDO) rather than liver enzyme tryptophan 2,3-dioxygenase (TDO) in the alterations of kynurenine concentrations.

Nagendra et al. (1993) reported no changes in liver Trp 2,3-dioxygenase (TDO) nor in extrahepatic indol-3-ylamine 2,3-dioxygenase (IDO) activities in DS-treated rats.

The closed conformation is only observed in TDO crystals grown in the presence of L-tryptophan.

TDO exists in livers of humans, rats, mice and some, but not all, other animal species in two forms: the active haem-containing holoenzyme and the inactive haem-free apoenzyme in a proportion of ∼1 1 [ 10].

It is not clear if these concentrations could be reached in vivo in localized compartments even if IDO or TDO is induced in the absence of an increase in Trp availability and hence flux down the KP, which can occur either through exogenous Trp loading or by endogenous mechanisms.

If the substrate-binding mode in IDO is similar to that seen in xcTDO, proton abstraction by a proteinaceous base is only possible in TDO, with the active-site histidine (His in xcTDO) being the only basic residue in the active site of either enzyme.

More than 90%% of tryptophan is catabolised to kynurenine, mainly in the liver by the tryptophan specific enzyme tryptophan 2,3-dioxygenase (TDO), but also in lungs, kidneys, spleen, placenta and blood by the enzyme indole 2,3-dioxygenase (IDO) [ 9].

In TDO the dental defects are enamel hypoplasia and taurodontism.

The TDO haem saturation in these species is therefore ∼0.5 as a ratio or ∼50% as a percentage.