Sentence examples for tdg it from inspiring English sources

Given the significantly different roles of p300 and CBP, as well as the fact that CBP directly interacts with RARs in a ligand-dependent manner in the absence of TDG, it is not only more challenging to show such a ternary complex, but also of significant interest to uncover a mutual stabilization within the complex.

Soco said it would do further studies before deciding the future of the Te Giac Den (TDG) exploration block, where it owns a 30.5% stake.

We performed NMR studies in order to assess the structure of TDG P65A and compared it to that of wild-type TDG.

It is noteworthy that TDG expression in e14.5 e16.5 germ cells is coincident with the presence of 5hmC, 5fC and 5caC.

Recent studies suggest that DNA demethylation can be achieved through ten-eleven Tetnslocation (Tet) family of DNA deoxygenates mediated oxidation followed by thymine DNA glycosylase (TDG) mediated excision and repair, but it is unclear to what extent such active demethylation processes take place.

► A somatic TDG mutation was found associated with TDG expression loss in the tumor.

As it was recently reported that TDG inactivation may promote DNA hypermethylation [30,31], we considered the possibility that TDG haploinsufficiency may do the same, which might have resulted in silencing of the wild type allele in the neoplastic tissue.

This could be potentially explained by a ternary complex forming between all three compounds, as it has been previously shown for TDG, RAR and the CBP-related HAT p300 [23].

The single interactions between each two of the three compounds add up to a high affinity complex in vitro, which may activate RA-dependent gene expression in vivo in a similar way as it has been suggested for RARα, TDG and p300 [23].

As TDG is apparently not involved in removing these modifications, it is thought that they are lost during DNA replication (Inoue et al., 2011; Santos et al., 2013).

It will thus be necessary to revisit TDG's activity as a 5-meC glycosylase under conditions that support the formation of these posttranslational modifications.