Sentence examples for tcr it from inspiring English sources

If pMHC thoroughly disengages from TCR, it will most likely escape.

Given the classical role of MHC class I molecules interacting with TCR it is an intriguing possibility that there is a functional connection between the UT molecules and TCRμ, whereby UT present antigen to TCRμ+ T cells.

As the CDR3 region is the most variable part of the γδ TCR, it is possible that a subset of γδ T cells can recognise diverse lipid cargoes presented by CD1 molecules, in a similar way to αβ TCR recognition of peptides bound to MHC.

In agreement with the prediction from TIM and TCR, it has recently been shown that on average, the rates of substitutions G→T, A→G, and C→T are increased on the coding strand and decreased on the noncoding strand (Mugal et al. 2009).

The presence of an S107 increased antigen sensitivity ∼100 fold in the PA19 TCR whereas it abolished recognition in the 3A9 TCR (Fig. 4c, d).

This demonstrated the coreceptor independence of CL3 TCR and it was consistent with the recognition of CaPo13 cells also by the CL3 transducedransduced T cells.

While this indicates that a substantial part of the Treg phenotype (measured at the population level) is dependent on persistent TCR signaling, it also shows that perhaps the majority of the Treg gene expression pattern is independent of this.

With such a low level of TCR expression, it is more than likely that T cell expansion is reduced due to a decrease in T cell sensitivity that results from a loss of interaction with self-ligands known to be necessary to promote T cell responsiveness to foreign Ag [28], [29], [30], [31], [32], [33].

Since most of the T cells responding to these peptide vaccines expressed Vβ8 TCR genes, it was not clear whether the peptides elicited different repertoires of T cells.

Upon TCR engaging, it has been reported that the formation of the immunological synapse triggers early store-dependent Ca2+ influx through mitochondrial Ca2+ buffering (Hoth et al., 1997; Quintana et al., 2007).

T cell response is triggered by an initial signal delivered through the T cell receptor (TCR), and it recognizes the antigenic peptide within the context of the major histocompatibility complex (MHC) molecule on the antigen-presenting cells (APC).