Exact(1)
Plates were washed in barbital-T and subsequently incubated with anti-C4c (0.13 µg/ml), anti-C4c-biotin (2 µg/ml), anti-C3c (0.32 µg/ml) or anti-C5b-C9 (TCC) (1 µg/ml) for 2 h, shaking at room temperature.
Similar(58)
The nucleotide substitution from C to T resulted in CCC (other varieties) and TCC (ST12) sequence context, respectively (Fig. 2a).
The remaining 10%% arise in the penile urethra, of which 90%% are SCC and 10%% are TCC [6, 10] (Fig. 2).
The TCR Vα and Vβ chains of three out of five TCR clonotypes analyzed were detected in TILs (TCC 22N, TCC CL3, TCC CL54).
Stage III: 26H (RCC), 26I (transitional cell carcinoma, TCC), 26J (clear cell ADC), 26K (m, TCC).
This is consistent with the CD8-independence of the original TCC CL3 clone.
Indirectly, this result also confirmed that TCC CL3 was specific for the autologous tumor cells.
VEGF protein has been found to be significantly over-expressed in all grades and stages of TCC [81], [82], [83].
VEGFA over-expression has been found to be a good indicator of poor survival in patients with TCC [78], [79].
This suggested that TCC CL3 could be outcompeted in vitro by the growth of other TCCs present in TILs that responded better to the polyclonal stimulus.
The percent change per time window (n = 22) (typically a two-week period) ranged from 1 to 16% (mean ± standard deviation [ x̅] = 7 ± 5%) for TCC, 1 39% (x̅ = 12 ± 11%) for 2′ OH-TCC, 1–132′ OH-TCC31 1321%) for 3′–OH-TCC, 1–39% (x̅ = 131± 12%) for 31%Cl-TCC, and 0.4–26% (x̅ = 7 ± 7%) for TCS, where the ranges and averages were calculated using absolute values of the concentration differences.
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