IFN-γ producing CD4+ T cells provide the major effector response to TB but while IFN-γ is required for protection against disease progression in TB it is not sufficient on its own [2].
Twenty five active TB children had QF-TB-IT values at day 0 and day 180.
Distributions of QF-TB-IT for all groups were represented using box and whiskers plots.
Thirty eight LTBI children had QF-TB-IT at day 0 and day 90.
By comparison only 9% of HC had a positive QF-TB-IT result.
The QF-TB-IT was sampled at day of inclusion (day 0) for all children.
By so, we presented data regarding the behavior of QF-TB-IT only, for each category.
30%, 9%, 58% and 78% of controls, HC, LTB infected and active TB children respectively were QF-TB-IT positive (Data S1).
The study was performed blind as clinicians responsible were not provided the QF-TB-IT results throughout the study.
This rate was significantly lower than the rate of positive QF-TB-IT in these children (p = 0.021, Liddell test).
