We argue that this indicates a missed opportunity for childhood TB case detection, as childhood TB is not suspected in the early stages of the disease where symptoms are less severe and more general.
Tuberculosis (TB) predominately presents with pulmonary disease, although extra-pulmonary TB is not uncommon [ 1- 4].
In the EU setting, composed of numerous low-incidence countries where medical doctors have little opportunity to investigate a TB patient, there is a real risk that TB is not considered when a coughing patient reports to healthcare services.
However, treatment of active TB is not sufficient to eliminate the disease, because individuals with latent TB infection (LTBI) outnumber those with active TB, and LTBI can progress to active disease at any time [ 2].
Hence diagnosing gastrointestinal TB requires a high index of suspicion, especially in countries where TB is not endemic.
In line with a long tradition of thought, we hypothesize that TB is not only an infectious disease, but also a bona fide genetic disorder; more specifically, we hypothesize that TB results from inborn errors of immunity [3], [8] [12].
3) In the EU setting, TB is not the leading cause of persistent cough and, thus, cough is not the leading sign or symptom of TB disease.
Recent research showed that bovine TB is not passed through direct contact between badgers and cattle, but through contaminated pasture and dung.
Even the diagnosis of "ocular TB" is not standardized [31].
Ocular TB is not easy to diagnose because most of the time there is no concurrent active systemic TB.
TB is not easily spread and close, prolonged contact is required for someone to be at risk of infection.
