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30%, 9%, 58% and 78% of controls, HC, LTB infected and active TB children respectively were QF-TB-IT positive (Data S1).
Strikingly, active TB children with a negative QF-TB-IT response at day 0, but a positive a day 10, were all culture positive.
Despite the fact that several culture negative active TB children had very high QF-TB-IT values (not shown), the geometric mean was no different when we compared it to the geometric mean calculated from culture positive active TB children IFN-γ values, although a trend was observed (see figure 3A).
Fourteen LTBI and active TB children with a negative QF-TB-IT response at day 0 rapidly developed a positive response after 10 days of preventive or curative therapy.
Results of QF-TB-IT were compared in active TB children according to culture, family contact and chest X-ray using the signed Wilcoxon rank sum test, while the proportions of QF-TB-IT and positive cultures were compared in these patients by the Liddell's exact test for paired data.
Finally, QF-TB-IT values were not significantly different in active TB children with positive and negative culture (p = 0.26, figure 3A), positive and negative chest X-ray (p = 0.31, figure 3B) or presence of family contact (p = 0.18, figure 3C).
Similar(27)
This makes the diagnosis of TB in children challenging as children most often have pauci-bacillary pulmonary TB resulting in smear-negative pulmonary TB; and also a higher proportion of childhood TB presents as extra-pulmonary TB (EP-TB).
Approximately one million of those infected with TB were children, and nearly 200,000 children died of TB in the past year.
We developed a Markov model which reflects the natural course of TB in children and represents 3 significant age groups associated with progression to TB disease and TB mortality in children up to 10 years.
Tuberculosis (TB) in children is a serious condition, and in endemic regions TB is a likely cause of death among children with symptoms of respiratory infection [ 1].
This study was designed to evaluate the demographic, clinical, and laboratory findings and outcomes of TB in children with emphasis on central nervous system (CNS) complications.
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