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Incident TB during ART is often due to "unmasking" of reactivated TB because of restoration of TB antigen-specific functional immune responses.
Diagnosis through this standard approach is assumed to occur at a given constant rate; in calculating this rate, we assumed that the delay in diagnosing TB-NSP would be twice that for adult pulmonary TB because of the difficulty in obtaining a sample from the site of infection (e.g. pleural aspirate or gastric fluid) for diagnosis [ 34].
"If you consider the number of patients who have been cured of TB because of the rat technology, the impact is huge," he says.
He added: "The multi-drug resistance is a worry because this gets into an area where we're losing the ability to treat TB because of the lack of antibiotics".
Fixed dose combination (FDC) formulations became popular in the treatment of tuberculosis (TB) because of the better patient compliance, reduced risk of monotherapy and emergence of drug resistance in contrast to treatment with separate formulations of two to four first-line drugs.
TB: Because of all the techniques we were using, there was no point in shooting it in 3-D when there's nothing to shoot.
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We opted not to present a pooled prevalence ratio for the overall association between HIV infection and MDR-TB because of the high degree of heterogeneity among studies.
Physiotherapy and occupational therapy are often withheld from in-patients with TB, especially patients with MDR/XDR-TB, because of the risk of infection for the hospital staff.
This pattern shows some differences from the advice-seeking network for TB because none of the physicians sought advice from outside the district.
Possible reasons for this situation given by doctors in interviews included: first that the quality of services for diagnosis and treatment of TB was better at general hospitals than at the TB dispensaries; and second, that some TB suspects/cases would be reluctant to be referred to the TB dispensaries because of the fear of stigma.
Multidrug resistant tuberculosis (MDR-TB), defined as Mycobacterium tuberculosis resistant to isoniazid and rifampin, further threatens TB control because of high treatment failure and death rates, and complexities in diagnosis and treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com