Sentence examples for tat region from inspiring English sources
The SUMA Tat region was also was the only region studied that contained overlapping epitopes, recognized by 3 distinct early CD8+ T-lymphocyte responses focused in this region [4]; thus the more complex pattern of early escape in SUMA Tat might have been a consequence of multiple distinct selective pressures from distinct T-lymphocyte responses.
For T. cruzi, TAT has been annotated in nine contigs in GeneDB, in most cases at the end of a contig or in a small contig by itself, indicating that the assembler used for the whole genome assembly of T. cruzi (Celera assembler, [ 29]) was not able to extend the contigs in the TAT regions due to repeats.
In this work, we describe a novel approach toward screening fragments against RNA that uses a chemical probe to target the Tat-binding region of TAR.
Cynics call it Titanic tat.
Cells were incubated with the peptide and a version of the TAT-14 peptide scrambled in the 14mer region (TAT-14Sc), which would affect binding to the Kelch domain but the peptide would still enter the cell (see Figure 1C).
The Tat C-terminal region is of significant importance for its extracellular activity.
Amino acids 37 48 correspond to the core region in Tat, which is necessary for Tat transactivation (reviewed in [50]).
Our results suggest that the ubiquitination and carboxyl-terminal region of Tat are involved in the regulation of Tat stability and activities.
To investigate the roles of the ubiquitination and carboxyl-terminal region of Tat in the regulation of its stability, we firstly constructed GFP-tagged full-length Tat (GFP-Tat101) and the truncated forms (GFP-Tat86 and GFP-Tat72) as shown in Figure 1A.
As for the effects of the carboxyl-terminal region of Tat on its transactivation activity, luciferase reporter assays were performed and the results revealed that full-length Tat and the two truncated mutants resembled each other in transactivation ability in the absence of MG132.
