Exact(1)
These differences arise from complex interactions between biological and environmental factors, which include genetic diversity affecting drug metabolism and the expression of drug targets, variations in tumour biology and host physiology, socioeconomic disparities, and regional preferences in treatment standards.
Similar(59)
Drug molecules designed along those principles are usually rigid and unable to adapt to target variations arising from naturally occurring genetic polymorphisms or drug-induced resistant mutations.
The films were grown in two target variations.
More advanced pipelines avoid exposing stalls from the ISA in order to avoid too many (compiler) target variations and retain binary compatibility between processor versions.
Because of the small numbers of miRNA members and target genes, target variations #5, #10, #11, #15, and #16 in Table 1 had no significant GO terms.
The target variations and their corresponding 5' and 3' flanking sequences must be entered to the given text box or upload a file containing the information to the server.
Evaluation showed that miRNA-centric μ measure exhibited the best specificity and homogeneity except only for the target variations #12, #19 and #22.
50% of off target variations (n=1,291), in fact, were not called in the scout pools and were easily filtered off during bionformatic analysis.
They also determined how many copies, if any, the children carried of the target variation.
[7] Still, this corresponds roughly to leaving out a single target out of 14 in the NNRTI set (+/− 10% of target variation).
Finally, we investigated the extent of off-target variation and its effect on genotype calls.
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