Among proximal targets under discussion are those involved in insulin resistance, insulin/IFG-1 system, and fatty acid oxidation and utilization [ 7, 69- 71], which were considered earlier with regard to the antiaging effects of phenformin [ 3, 14, 72].
Glucose control strategies and recommendations on HbA1c targets are currently under discussion since findings from recently published trials, such as ACCORD, ADVANCE and VADT have not demonstrated a significant reduction in cardiovascular disease with intensive glycemic control [ 22, 23].
Climate change officials at the country's industry and environment ministries denied the Nikkei and Kyodo reports, saying the target was still under discussion.
They require, he said, "tough, separate negotiations," possibly the threat of specifically targeted new sanctions — "some already under discussion in the Congress" — not a tendentious claim that Iran is not in compliance with the deal.
The Chinese leadership was noncommittal on the access question, as well as the substantive matters still under discussion -- the targeting of nuclear missiles, the spread of weapons technology and human rights.
The new package of measures is still under discussion to reach a target of 5.8bn euros demanded by the EU and IMF, and may include a revised bank levy.
Hence, the physiological value and clinical impact of commonly used specific targets, and the relationship between macro- and microhemodynamia, remain under discussion.
Reshaping the list of targets for America's nuclear warheads, officials said, also is under discussion.
Officials cautioned the operation under discussion involved a limited, precise set of targets that would be of a short duration, unlike the broader campaign against Libya in March 2011.
It now looks unlikely to achieve that target, but the idea of a single currency for all of Africa is still under discussion.
Moreover, the Europeans have yet to agree on long-term emission targets that would drive up carbon prices and reward investors in clean energy, though proposals are under discussion.
