Sentence examples for targets to develop novel from inspiring English sources

The rising incidence of diabetes and confines allied with clinical therapies emphasized the need to explore new molecular targets to develop novel, effective and safer antihyperglycemic agents.

Therefore, there is an urgent need to discover new druggable targets to develop novel glioma treatments that might enhance patient survival.

Even though PPI interfaces are very interesting targets to develop novel molecules, there are still not promising examples of drugs designed against TA interfaces.

Several prognostic markers exist, and recent studies have indicated promising new targets to develop novel strategies for systemic therapies in endometrial cancer (Salvesen et al, 2009).

Bacterial DNA gyrase is a well-established and clinically validated target to develop novel antibacterial.

ftsZ (Rv2150c), a bacterial tubulin homologue involved in essential cell division, is considered as an attractive target to develop novel anti-TB drugs, as well as new broad-spectrum antibacterial agents [40].

Due to early crystallographic evidence, plasmepsin II (Plm II) emerged as well explored target to develop novel antimalarials as well as a starting point to develop inhibitors targeting some other subtypes of plasmepsins i.e. Plm I, II, IV and V.

Thus, Na,K-ATPase might serve as a valid target to develop novel therapeutic approaches in tumors with aberrant activation of the EGFR signaling cascades.

Specific inhibition of sPLA2 IIa may, therefore, be a valid target to develop novel disease modifying anti-rheumatic drugs (DMARDs) which are more efficacious than existing therapies, given high concentrations of sPLA2 IIa in arthritic joints [ 23].

While cardiac glycosides might not prove useful in all tumor types as anticancer therapeutics, we suggest that Na,K-ATPase is an attractive target to develop novel therapeutic strategies for medulloblastoma with aberrant activation of EGFR signaling.

Hence, it has become inevitable to identify new drug targets and to develop novel drugs against L.donovani to cure Leishmaniasis.