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Exact(7)
An interaction is quantified in terms of the number of common targets (s) or the number of proteins on which the activity of two drugs differs (d).
There was no difference between the background matching and disruptive targets (S(1) < 0.01, P = 1.000).
For targets, S t topo(t p, t q ) holds the similar consideration.
There were non-significant trends (using sequential Bonferroni critical P-value threshold adjustment; see Methods) between the banded and gray targets (S(1) = 4.57, P = 0.033), and between the white and interval-striped targets (S(1) = 3.56, P = 0.059).
In an attempt to address issues related to overparameterization, the article further developed and tested an approximated model for the two targets (S and M) case.
On the other hand, if one were to formulate the assignment g so that the targets s τ are assigned a random choice of criteria from the entire set γ (note that the allowed choices for ITR and BFS are restricted to a smaller set), such method can only achieve a similarity value of 0.051 with the target criteria τ.
Similar(53)
In TB Mobile, a molecule that targets S-adenosylhomocysteine hydrolase (SahH, Rv3248c) is ranked first while the known alr inhibitor, D-cycloserine is ranked 12th out of the set of over 700 compounds (Additional file 1: Figure S1).
The majority of these targets were enzymes responsible for carbohydrate and fatty acid catabolism, and we demonstrated that for three of these targets S-nitrosation reversibly inhibited enzymatic activity.
As epigenetic action of DAC targets S-phase fraction of cells, prevalent appearance of lymphocytes in G0/G1 phase of cell cycle is the possible reason of high lymphocyte resistance to low DAC concentration exposure.
The molecular target(s) of DMXAA remains unclear.
Its specific antitumor target(s) has still remained elusive.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com