This allows us to identify biological targets relevant to each category of performance-enhancing pharmacological activity.
We supplied the algorithms with subtrees of the humane kinome tree that contain only targets relevant to a subset (see Figure 7).
An alternative strategy could be the use of agents designed to inhibit simultaneously multiple cellular targets relevant to tumour growth/survival.
As proof-of-concept, and in an effort to uncover new cardiac-specific targets relevant for therapeutic applications, we performed global epigenetic and transcriptional analyses during cardiac specification using this protocol.
In addition, an NAD+-dependent enzyme was used to impart selectivity to the biosensor, which also represents a class of enzymes with targets relevant to the health and food industry.
Other targets relevant to Alzheimer's disease have also been considered in the last years for producing multitarget compounds such as β-secretase, monoamino oxidases, serotonin receptors and sigma 1 receptors.
