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Reg1p directs Glc7p to its targets, participating in the regulation of several processes such as glucose de-repression and glycogen synthesis [49], [50].
The results indicated that the four candidate genes are promising targets participating in the regulation of TA in this region.
Searching for molecular targets participating in the process of drug-resistance and utilizing these targets to oppose drug-resistance in chemotherapy will be beneficial to the clinical therapy.
The miRNAs and their targets participating in reproductive development in angiosperms, such as miR156-SPLs, miR159-MYBs, miR172- AP2Ls, miR319-TCP and miR396-GRFs, were also found in P. tabuliformis.
This was even more obvious for the 93 target genes of preserved miRNAs with only 17 targets participating in at least one significant KEGG pathway (18%), which suggest that KEGG pathways are more significant in dysregulated miRNAs than preserved miRNAs.
Among all functional categories, targets involved in nuclear components occupied the highest frequency, followed by targets participating in DNA-dependent transcription, DNA-dependent regulation of transcription, and DNA binding, respectively, indicating that most targets were transcription factors.
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In total, 185 human sulfenylated proteins showed homology to sulfenylated plant proteins and the conserved sulfenylation targets participated in specific biological pathways and metabolic processes.
Moreover, for connections with enrichment |score|>1.25 (i.e. P<0.002), more than half (28 out of 51, vs. 21.3% by random chance) of connected targets participate in at least one common pathway.
Did targets participate?
And did targets participate well?
According to the KEGG analysis, all of the targets participate in the MAPK pathway.
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