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Adding, that it should be driven deep into the operations of a company, embedded in the job descriptions and targets of key personnel and running through the supply chains of major companies.
To further study the potential targets of key ovarian miRNAs, we overexpressed miR-34c, miR-98, miR-424, and let-7f in 2 ovarian cancer cell lines (BG-1 and UCI-101).
We therefore systematically analyzed the in vivo, transcriptome-wide targets of key factors in this pathway in budding yeast.
Analyzing the direct targets of key transcriptional regulators including HLH-2, TRA-1, and FKH-6 may provide insight into how the gonadal sex differences are established.
In this manuscript we present a case study that indicates that the combination of micro-array analysis and targeted knockdown of essential embryonic genes in zebrafish can provide new insights in the specific targets of key regulators of development.
Next, we asked if it is possible to determine the downstream targets of key pluripotency genes by analyzing genes that were downregulated in the day 5 outgrowth that had just ceased to be pluripotent.
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This involved a relentless focus on local issues and targeting of key voters as well as shrewd mobilisation of resources, both human and statistical.
We conclude that CENP-E integrates two critical functions that are important for accurate chromosome movement and spindle architecture: one relying directly on its motor activity, and the other involving the targeting of key microtubule regulators to kinetochores.
These agents offer the potential for selective targeting of key processes in the pathogenesis of psoriasis.
Pharmacological targeting of key signaling components, including multi-pathway proteins and miRNAs is a promising strategy [ 53- 55].
A better understanding of the pathogenesis of RA has improved treatment of the disease, particularly the targeting of key molecules by biologics [ 3– 5].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com