Sentence examples for targets of compounds from inspiring English sources
The known targets of compounds in FFDS were collected from STITCH62 (http://stitch.embl.de/, version 5.0) with a higher interaction score (confidence >= 0.7).
Computational chemogenomic (canSAR) analysis of prostate cancer mutations identified 11 targets of approved drugs, 7 targets of investigational drugs, and 62 targets of compounds that may be active and should be considered candidates for future clinical trials.
Cell-based assays based on disease-specific phenotypes, such as cell proliferation, migration, and invasion in the case of cancers, have been used to identify lead compounds1, 2. However, elucidation of the MoA and molecular targets of compounds obtained by phenotypic screening remains challenging, and is therefore a rate-limiting step for drug discovery using cell-based assays.
This may be useful for suggesting potential additional targets of compounds for which it is still unclear.
Finally, we used CRISPR/ Cas9-targeted mutagenesis in zebrafish to genetically validate predicted targets of compounds.
Identification of unique recurrent single nucleotide variations (SNVs) or expression alterations that enable resistance can offer insights into the mechanism of action or cellular targets of compounds.
Therefore, we have successfully obtained compound 3 as a suitable ABPP probe to identify potential molecular targets of compound 1.
Inherently, the identification of targets of compound hits originating from cellular screens requires deconvolution.
Among the current trends in the development of biopesticides is the control of release rate and targeting of compounds by nanoencapsulation, as this technique can increase the stability and solubility of natural products and, consequently, increase their efficacy.
Reduction of beta-amyloid levels is a common target of compounds (such as apomorphine) under investigation.
Straightforward applications of the concept of chemical similarity (28), they search the BindingDB dataset for compounds similar to a query compound, and suggest the targets of these compounds as potential targets of the query compound.
