Sentence examples for targets internalized from inspiring English sources

These studies also show that the ubiquitin-binding autophagy adapter protein p62 targets internalized GJs for degradation via the autophagosomal route [ 51, 54].

Downregulation of p62/SQSTM1 expression resulted in the highest, statistically significant increase of the number of cytoplasmic GJ vesicles in our study by 55 ± 4% (n = 4) (Fig. 6C), further supporting our hypothesis that p62/SQSTM1 targets internalized, ubiquitinated AGJ vesicles to autophagic degradation.

Recently Knight et al. presented a new pretargeted approach called HaloTag enzyme for the pretargeting of two targets: internalizing HER2 and non-internalizing TAG-72 [18].

Some targets internalize frequently regardless of ligand binding, whereas others reside permanently on the cell surface.

In case of the αβTCR it was shown that the Casitas B-lineage lymphoma proteins c-Cbl and Cbl-b (RING-type E3 ubiquitin ligases) together with Cbl adaptor proteins Src-like adaptor protein SLAP and ζ-associated protein ZAP70, target internalized ζ chains to degradation by lysosomes [ 36- 39].

While the field has generally moved away from linkers that provide slow nonspecific cleavage of the ADC (such as the hydrazone linker used to prepare Mylotarg) due to concerns about toxicity arising from premature drug release, the rationale for engineering a half-life into the linker here was to use it with antibodies targeting poorly internalized antigens.

Therefore, Mtb P-type ATPases could be possible targets for the design of inhibitors that are capable of acting on their targets without being internalized by the mycobacterial cell.

The exact nature of the exploit isn't disclosed, but the whole idea of Tay was a bot that would learn the lingo of its target demographic, internalizing the verbal idiosyncrasies of the 18-24 social-media-savvy crowd and redeploying them in sassy and charming ways.

These findings provide evidence for the role of stigma resistance as a viable target to fight internalized stigma and improve the treatment adherence of people with schizophrenia.

22, 23 In order to obtain optimum efficacy, an ADC target must be internalized to permit transfer of the cytotoxic drug inside cancer cells.

A fundamental limitation of many agonists acting at G-protein coupled receptors, such as apelin, is that after stimulating G-protein pathways to elicit a physiological response, the target receptor is internalized and silenced via the β-arrestin pathway.