Exact(16)
They represent potential therapeutic targets in prostate cancer.
To our knowledge, this is the first report identifying SNO targets in prostate epithelial cells.
A significance cutoff of E< = 150 was chosen because it minimized the FDR (at about 0.1) and included all well-studied AR targets in prostate cancer cells.
This cutoff also included all features with fold changes of 1.5 or greater, and included all well-studied AR targets in prostate cells.
Hence, HER family receptors have become potential therapeutic targets in prostate cancer [ 47].
However, to be fully understood, the precise mechanism of miR-146a action (its specific gene targets) in prostate cancer progression warrants investigation.
Similar(44)
PSMA is a particularly important molecular target in prostate cancer patients with negative bone scans who are at high risk for metastatic disease.
The aldo-keto reductase 1C3 (AKR1C3) isoform plays a vital role in the biosynthesis of androgens and is considered an attractive target in prostate cancer (PCa).
That's exciting, says co-author Mark Rubin, a pathologist at Weill Cornell Medical College in New York City, because this pathway may be a "druggable" target in prostate cancer.
The potential of PACE4 as a pharmacological target in prostate cancer has been demonstrated as this proprotein convertase is strongly overexpressed in human prostate cancer tissues and its inhibition, using molecular or pharmacological approaches, results in reduced cell proliferation and tumor progression in mouse tumor xenograft models.
We show here that ERK5 is a miR-143 target in prostate cancer.
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