Sentence examples for targets impact from inspiring English sources

By degrading dietary substrates, the gut microbiota produces several metabolites that bind human pharmacological targets, impact subsequent signalling networks and in fine modulate host's metabolism.

Combination strategies that address the complexity of the integrative networks on which these molecular targets impact are now emerging.

Additional modeling and simulation is needed to address how local targets impact systemic and target site drug exposure.

This morning the Director of National Intelligence DNII) released a report detailing its use of various legal authorities in 2013 to execute surveillance, and the number of targets impacted by each method.

However, no validated modelling strategy has been published in literature for UHMW-PE composite that captures the penetration and damage mechanisms of thick targets impacted between 900 m/s and 2000 m/s.

We discuss why shRNA knockdown of targets impacted the KO cells more than WT cells: "Repression of miR-142-3p miR-142-3p miR-142-3pets was found to be sufficient in restoring PPF levels in miR-142-deficient MKs.

Principal among these is determining whether the observed changes in miRNA expression levels reflect a causal pathway between exposure and outcome, identifying the downstream gene targets impacted by deregulated miRNAs, and delineating variability introduced because of methodological and biospecimen specifications.

Specifically, KOG, a eukaryotic representation of the Clusters of Orthologous Groups (COG) database [ 34], identities for all differentially expressed transcripts were leveraged to determine which metabolic pathways represented the primary functional targets impacted by RDX exposure.

b Photograph of soft-point hunting bullets depicting the soft-point construct and incomplete hard-metal jacket; significant deformation of this bullet caused by target impact is also depicted.

This implies that ZnO NPs may have targeted impact on coelomocytes as a result of preferential accumulation and subsequent in situ molecular damages by liberated Zn+ ions [2] at higher concentration.

Aim: The main reason to use the nanoparticles is to make active substrate not to decay at the injection site, to target impact zones, to provide continuous active substrate oscillation and to improve the bioeffect of administration of drug.