Sentence examples for targets have evolved from inspiring English sources

We expect that lead libraries biased towards molecules that biological targets have evolved to recognize, would yield better hits rates, than unbiased or universal libraries.

Perhaps, FruM isoforms and their gene targets have evolved to take advantage of the unique properties of the male nucleus.

In recent years, tumor drug targeting has evolved as a promising strategy to increase local drug concentration and reduce systemic side effects.

Elements belonging to some CR subfamilies are enriched at the centromeres of grass (Miller et al. 1998) and other plant (Weber and Schmidt 2009) species; however, it remains unclear whether centromere targeting has evolved because these insertions are less likely to result in gene disruption or because CR elements actually contribute to centromere function in grasses.

Unlike these targets, which have evolved to bind small molecules, PPIs have no convenient natural substrate to serve as a starting point for small-molecule design.

These findings, and the conservation of miRNA/target-pairs described before, provide further evidence that particular miRNAs and their corresponding targets must have evolved early in land plant evolution and were then conserved widely throughout the plant radiation.

Targeted therapies have evolved in medicine following advances in molecular technology and the successful mapping of the human genome.

To better understand how target sites have evolved with the emergence of cattle-specific miRNAs, we first evaluated whether the cattle-specific miRNAs have a greater proportion of targets that are also cattle-specific.

Few of the targets identified in our study correspond to known Dsx transcriptional targets in D. melanogaster[ 28], suggesting that the targets of Dsx have evolved rapidly within the Diptera and highlighting the need to pursue analysis of dsx function in mosquitoes.

They are unique from other RNA targets because they have evolved to form specific structural receptors for the purpose of binding small molecular metabolites suggesting that structure-based rational drug design approach may be used in designing metabolite mimics targeting riboswitches.

As a first step towards mediating directed DNA rearrangements at non-native Flp recombination targets (mFRTs), we have evolved three separate groups of Flp variants that preferentially act on mFRTs containing substitutions at the first, seventh or both positions of the Flp-binding elements.