Herein, we sought to identify molecular targets for therapy by using targeted RNA/DNA sequencing and gene expression of key immunological players.
Garin, A. & Proudfoot, A. E. Chemokines as targets for therapy.
This underlies the need to better understand the biology of this tumor in order to identify novel targets for therapy.
The group is pursuing genetic and genomic research to identify targets for therapy in blinding eye diseases.
We will be using the YY1 platform to uncover novel targets for therapy using proteomic, metabolic and genomic approaches.
We try to identify oncogenes and biomarkers of aggressive disease that might be targets for therapy," Drapkin explains.
Significantly, the dysregulated genes and pathways, and in particular Chmp7/CHMP7 identified by our transcriptomic profiling may serve as candidate druggable molecular targets for therapy development in SBMA.
As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes.
Leukaemia stem cells (LSCs) are responsible for sustaining and propagating malignant disease, and, as such, are promising targets for therapy.
The AR and PI3K/Akt/mTOR signaling pathways are the two most frequently altered, representing therefore interestingly targets for therapy.
Amyloid β (Aβ) aggregates are considered as possible targets for therapy and/or diagnosis of Alzheimer disease (AD).
