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Here, we present our rationale suggesting why such potent early CTL responses that exert an antiviral effect may be particularly attractive targets for induction by candidate vaccines.
These nodes are potential therapeutic targets for induction of apoptosis in leukemic T-LGL.
To further demonstrate that antisense nc-rRNAs are potential targets for induction of apoptosis, additional complementary LNAs listed in Supplementary Figure S1a were tested.
Interestingly, several protein tyrosine phosphatases that can deactivate STAT3 signaling through direct dephosphorylation of p-STAT3 (Tyr 705) might be useful targets for induction of cancer cell death.
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Although Ali had already been declared ineligible for military service, the Army changed its eligibility standards, and suddenly Ali was targeted for induction.
To ascertain which of the Akap12 isoforms is targeted for induction with retinoids, exon-specific probes to each Akap12 isoform were designed and applied to samples of RNA from atRA-stimulated PAC1 SMC.
Such studies will help identify protective long‐lived IgG MBC specificities that can then be targeted for induction by vaccination.
However, N-Myc is likely to be a critical Wig-1 target for induction of differentiation as the SH-SY5Y neuroblastoma cells that do not express N-Myc fail to differentiate upon Wig-1 knockdown (Supplementary Figure S3b and c).
The SCGE assay with rodent cells has the advantage that HA-induced DNA damage can be monitored in a variety of organs which are targets for tumor induction by HAs.
Sphingomyelin phosphodiesterase, phospholipase A2 and lysosomal phospholipase A1 are shown to be likely targets for the induction of phospholipidosis by inhibition of phospholipase activity, while lanosterol synthase is predicted to be associated with phospholipidosis being induced by enhanced cholesterol biosynthesis.
Furthermore, this study provides evidence that sphingomyelin phosphodiesterase, phospholipase A2 and lysosomal phospholipase A1 are all likely targets for the induction of phospholipidosis by inhibition of phospholipase activity, while lanosterol synthase is expected to be associated with phospholipidosis occurring due to enhanced cholesterol biosynthesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com