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8 Viral entry plays an important role in the pathogenesis of HCV infection, especially during HCV reinfection of the graft after LT. 9 10 Targets for entry inhibitors include CD81, scavenger receptor class B type I (SR-BI), tight junction proteins CLDN1 and occludin, epidermal growth factor receptor (EGFR) 8 11 and Nieman-Pick C1-Like 1. 12 Entry inhibitors exhibit a broad pan-genotypic activity.
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EADS said the production schedule for the A350, which has a late-2014 target for entry into service, remained "challenging" and cautioned that unforeseen delays could lead to fresh provisions to compensate airline customers.
The envelope glycoprotein of HIV-1 is the principal target for entry inhibitors.
Env is the target for entry inhibitors [8] and neutralizing antibodies directed against gp120 and gp41 [9].
In eukaryotes, newly synthesised proteins are typically targeted for entry into the general secretory pathway by the presence of a N-terminal signal sequence that typically has a length between 15 to 30 amino acids and comprises a central hydrophobic region flanked by hydrophilic N- and C- terminal regions [ 9].
He said universities should set their own targets for widening entry and decide how best to achieve them.
She ruled out imposing targets for direct entry recruits, but told the audience: "I urge you to see it for what it is: an opportunity to bring in talented leaders from different sectors".
That may help Turkey, as it ties Germany to the status quo of letting the talks go on.Mr Aktar suggests that individual EU countries which back Turkey should name an unofficial target date for entry: perhaps 2023, the centenary of the Turkish republic.
Most of these predictors are also modifiable and could potentially serve as targets for re-entry interventions.
In this study, we showed that the Ebola fusion peptide is able to use lipid rafts as a target for virus entry into cells, which could explain why cholesterol-depleted cells have impaired Ebola virus GP-pseudotype-virion entry and fusion [35].
"The mucosal layers under the foreskin are a prime target for the entry of viruses, particularly H.I.V".
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