Sentence examples for targets for ameliorating from inspiring English sources

Therefore, chemokines (in addition to cytokines) likely represent important mediators of bladder injury and possible targets for ameliorating bladder inflammation.

ADAMTS proteoglycanases, including ADAMTS4 and ADAMTS5, degrade CSPGs, representing potential targets for ameliorating axonal growth-inhibition by CSPG accumulation after CNS injury.

Advances have been made in the identification of new growth factors and cytokines and their downstream signaling components, which are also important targets for ameliorating fibrosis.

Proteins that exhibit differential expression upon FUS knockdown (Table 1) may also serve as therapeutic targets for ameliorating the loss of FUS function in disease.

The proteins and pathways uncovered herein not only define the cellular consequences of FUS depletion, but also serve as potential therapeutic targets for ameliorating adverse phenotypes arising from a loss of FUS function.

ARD1 is a potential target for ameliorating oxidative injury or for potentiating ROS-producing anticancer agents.

Thus, PEDF may play a detrimental role in the maintenance of vascular integrity and may provide a new potential therapeutic target for ameliorating hyperpermeability.

Our findings suggest that DRP1 is a potential therapeutic target for ameliorating oxidative stress-mediated mt fission and dysfunction in RGC and its axons during glaucomatous neurodegeneration.

Furthermore, DRP1 inhibition blocks oxidative stress and rescues RGCs and their axons by preserving mt integrity, suggesting that DRP1 could be a potential therapeutic target for ameliorating oxidative stress-mediated mt fission and dysfunction in glaucomatous RGC degeneration.

Our findings suggest, for the first time to our knowledge, that miR-33a regulates cholesterol synthesis through the TGF-β1/Akt/SREBP-2 pashwell as well as cholesterol efflux-related genes ABCA1 and ApoA1, in OA chondrocytes, pointing to its identification as a novel target for ameliorating the OA phenotype.

These cumulative data suggest that T lymphocytes, and more specifically Tregs, provide an immunomodulatory IL-4 signal that protects motoneurons against M1 microglial-mediated neurotoxicity and that anti-inflammatory cytokine signalling may be a potential alternative target for ameliorating the devastating effects of neurodegenerative diseases.