Sentence examples for targets essential from inspiring English sources

Moreover, inhibition of autophagy using 3-methyladenine (3-MA) or small interfering RNA (siRNA) that targets essential autophagy gene ATG5 abrogated the ATPR-induced cell differentiation.

Current treatment regimens for pancreatic ductal adenocarcinoma (PDAC) yield poor 5-year survival, emphasizing the critical need to identify druggable targets essential for PDAC maintenance.

In addition, 6e showed similar inhibition potency against four serotypes of DENV, suggesting that it restrains some evolutionarily conserved targets essential for DENV replication.

The obtained results indicate that the tested DHP compounds can be considered as candidate molecules either for their further chemical modifications or for the more detailed studies to identify cell targets essential for neuroprotection and memory enhancing.

The combination of proteomics and metabonomics enabled us to identify several key targets essential to the antitumor activity of lovastatin.

As in vertebrates, Drosophila p53 regulates multiple targets essential for apoptosis, DNA repair and proliferation [ 14, 21, 41].

sgRNAs targeting essential (sgEss) and non-essential (sgNon) genes were used as controls.

One of the most effective countermeasure alternatives to antibiotics would be to target essential virulence mechanisms of typhoid fever.

Many pesticides target essential components of the nervous system such as the Na+ channel or glutamate receptor27.

Previously, transgenic resistance to Foc race 1 in banana has been reported from glasshouse testing using either anti-apoptosis genes8,15 or RNA interference targeting essential Foc genes16.

Since loss of essential genes is uniformly toxic in CRISPR-based screens, we also developed a small hairpin RNA (shRNA) library targeting essential genes.