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The reason for this multimodality approach is that each approach has different targets, effects, mechanisms and time-windows and no single therapy is clearly superior to others or unequivocally successful.
Our data suggest that Cd exposure induces a limited spectrum of estrogenic responses in vivo and that, in certain targets, effects of Cd might not be mediated via classical ER signaling through ERE-regulated genes.
These and other evidences such as inhibition of tumor cell production of cytokines, anti-angiogenesis, induction of apoptosis and others, suggest off targets effects for PIs, and hints to the concept of a new class of drugs against cancer with multiple anti-cancer effects.
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Responding faster to redundant stimuli is known as the 'redundant targets effect' [1].
Optimal therapeutics utilize the lowest possible effective dose while minimizing off-target effects.
It absolutely minimises off-target effects".
PD: What you're describing is off-target effects.
The first challenge includes off-target effects.
Off-target effects were eliminated by Sanger sequencing.
Given an input disease gene set, the algorithm selected drugs that maximized on target effects and minimized off target effects.
"No drugs are free of off-target effects," he notes.
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