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Identifying new drug targets, attaining regulatory approval from government agencies, and refining techniques in drug discovery and development are among the challenges that face the pharmaceutical industry today.
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For total number of targets attained, data were collapsed into four categories (zero or one target, two targets, three targets, and four or five targets attained).
There was also a highly significant trend toward decreased incidence with more targets attained.
Also, there was a trend toward decreased payments with more targets attained.
In addition to individual targets, the total number of targets attained was also used as an independent variable.
Increases in the number of targets attained among the laboratory targets were generally associated with decreased payments (Table 4).
Each increase in number of targets attained among the laboratory targets was associated with decreased hospitalized days (Table 3), and there was a significant trend toward fewer days with more targets attained.
We observed a dose-response relationship, reflected in the graded trend toward better outcomes with more targets attained.
The proportional hazards assumption was not violated for any of the targets or for the total number of targets attained (p > 0.05 by global test of Schoenfeld residuals).
Each increase in number of targets attained among the laboratory targets was associated with a statistically significantly decreased incidence of hospitalization (Table 3).
Only including those patients who did not attain any targets at baseline (n = 23) still gave a significant trend (P = 0.030) toward decreased hospital days with more targets attained at 6 months.
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