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For total number of targets attained, data were collapsed into four categories (zero or one target, two targets, three targets, and four or five targets attained).
There was also a highly significant trend toward decreased incidence with more targets attained.
Also, there was a trend toward decreased payments with more targets attained.
Each increase in number of targets attained among the laboratory targets was associated with decreased hospitalized days (Table 3), and there was a significant trend toward fewer days with more targets attained.
In addition to individual targets, the total number of targets attained was also used as an independent variable.
We observed a dose-response relationship, reflected in the graded trend toward better outcomes with more targets attained.
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Identifying new drug targets, attaining regulatory approval from government agencies, and refining techniques in drug discovery and development are among the challenges that face the pharmaceutical industry today.
Importantly, our results also provide new evidence that each additional target attained results in incremental improvement in these outcomes, regardless of which targets are attained, and provide a comprehensive examination of a variety of performance measures and outcomes.
When all five targets were examined, a significant trend of decreased incidence of hospitalization with each additional target attained was seen (Table 3).
The same statistically significant trend of decreased hospital days with each additional target attained was seen when all five targets were examined (Table 3).
In subpopulation analyses of those attaining 0 or 1 targets at baseline, hospital admissions decreased even more strikingly with each additional 6-month target attained [IRR = 2 targets, 0.70 (0.55–0.89); 3 targets, 0.51 (0.40–0.65); 4 or 5 targets, 0.28 (0.16–0.50); P for trend<0.001].
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