But the level of savings required has not yet been identified and there is a "major risk to the delivery of the 2013/14 financial target as a consequence".
I want to convey my gratitude to you for your sincere empathy and willingness to venture outside of your comfort zone to stand shoulder-to-shoulder with Muslim women who are vulnerable to being targeted as a consequence of rising anti-Muslim intolerance and bigotry.
Their role in regulating a great variety of targets and, as a consequence, multiple pathways, makes their use in diagnostics a powerful tool to be exploited for early detection of disease, risk assessment and prognosis and for the design of innovative therapeutic strategies.
A specific feature of this kind of regulation is its promiscuity (the ability of one microRNA to interact with numerous targets) and, as a consequence, a multitude of effects (Carthew and Sontheimer 2009; Esquela-Kerscher and Slack 2006; Ma and Weinberg 2008).
We hypothesize that targeted therapies such as kinase inhibitors can produce off-target effects as a consequence of retroactivity alone.
Altogether, these five issues are the driving force in the specificity and selectivity of designed nanoconjugates toward their target, and, as a consequence, define their potential utility for biomedical application.
In order to test whether the low accumulation of the NIRF-Annexin V probe in the treated tumors was due to the specificity problems of the probe or due to a reduced delivery at the target site (as a consequence of the therapy-induced vascular breakdown), a second therapy study was performed applying a similar therapy design.
Trivially, these non-specific transcripts lack a common start position with respect to the intended target and, as a consequence, they, on the average, uniformly cover the probes of each probe set (see Figure 1a).
We thus have unraveled regulatory modules activated during acidic pH response in C. glutamicum (Fig. 6) and have identified targets as well as physiological consequences for the cellular stress response.
Water-soluble polymers for the delivery of chemotherapeutic drugs passively target solid tumors as a consequence of reduced renal clearance and the enhanced permeation and retention (EPR) effect.
