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Thus, downstream UPR targets alone are not best suited for accurate assessment and evaluation of UPR status, especially under physiological and disease settings.
Since the studies on drug targets alone are not sufficient to indicate the off-target effects, we need to develop computational models in order to simulate the effects of drugs on the signaling pathways.
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Reaching energy targets alone was not sufficient.
This suggests that presenting mothers with PA and SB targets alone is not sufficient to instigate behaviour change and that further actions are needed.
63 Berridge 64 argues that focusing on these educational targets alone is not enough, and that a theory and approach that encompass a wide view of the challenges faced by children in care are needed.
In clinical applications where binding to the target alone is sufficient for therapeutic efficacy; however, engagement of the immune system is not required and may even cause unwanted side-effects.
But a target alone is not enough.
Fasting and pre-dinner PG targets of ≤6.0 mmol/l were achieved by 25 and 20% of participants treated with insulin detemir and insulin glargine (NS), respectively; the pre-breakfast target alone was achieved by 46 and 58% (p < 0.01) and the pre-dinner target by 38 and 30%, respectively (p < 0.05).
51Cr release of target cells alone was always <25% of maximal 51Cr release (target cells in 0.25 M SDS).
Spontaneous release of LDH by the target cells alone was < 15% of the maximal release of LDH by target cells lysed in 1% NP-40.
Among miRNAs, miRNA 395, 172, and 164 target sequences alone were found in 831 contigs, showing the relative abundance of these miRNA target sequences in wheat.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com