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Focusing on a key cytokine signaling pathway previously implicated in cutaneous T-cell lymphoma pathogenesis, JAK/STAT signaling, we used conditional gene targeting to develop a fully penetrant small animal model of this disease that recapitulates many key features of mycosis fungoides, a common variant of cutaneous T-cell lymphoma.
We combined ideas from CD tagging and directed gene targeting to develop a method for directed fluorescent labeling of endogenous proteins in human cells.
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This paper is targeted to develop a profound structured approach to the ecosystem forecasting which combines scenario planning with technological forecasting.
In order to minimize vertebrate testing, this work was targeted to develop an in vitro test system as a possible model to assess the dermal uptake of chemicals across amphibian skin.
In 1997, while designing stylized scaffolding for the restoration of the Washington Monument, Graves also joined forces with mass retailer Target to develop a line of kitchen products ranging from toasters to spatulas.
IL-13 and its signal pathway are thought to be promising targets to develop a therapeutic agent for bronchial asthma.
This confirms the initial feeling of the scientific committee that the target to develop a new classification system corresponds to the needs of the scientific community.
This led us to postulate that these miRNAs may be detectable in mesotheliomas and could provide a useful target to develop a more sensitive test for the virus.
This confirms the initial feeling of the SC that the target to develop a new classification system corresponds to the needs of the scientific community.
Our study reveals a potential novel target to develop a biomarker for sepsis prognosis and therapeutic strategies.> -wrap-foot> > -wrap-foot> aARdataata of 19 patients were missing.
SVMs require the input of positive (known target) genes and negative (non-target) genes to develop a decision rule which can be used to classify new genes as bound or not bound by a TF.
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